TY  -  
T1  - BetaHPV E6 and E7 colocalize with NuMa in dividing keratinocytes 
SN  -  /  
UR  - http://hdl.handle.net/10138/320952 
T3  -  
A1  - Oswald, Evelyn; Kirschberg, Matthias; Aubin, Francois; Alonso, Angel; Hufbauer, Martin; Akguel, Baki; Auvinen, Eeva 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - Human papillomaviruses (HPVs) of genus betapapillomavirus (betaHPV) are implicated in skin carcinogenesis, but their exact role in keratinocyte transformation is poorly understood. We show an interaction of HPV5 and HPV8 oncoproteins E6 and E7 with the nuclear mitotic apparatus protein 1 (NuMA). Binding of E6 or E7 to NuMA induces little aneuploidy, cell cycle alterations, or aberrant centrosomes. Intracellular localization of NuMA is not altered by E6 and E7 expression in 2D cultures. However, ... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - Human papillomavirus; Betapapillomavirus; Nuclear mitotic apparatus protein 1; HUMAN-PAPILLOMAVIRUS TYPE-16; EARLY GENES; PROTEIN; EXPRESSION; DIFFERENTIATION; CHROMOSOME; ORGANIZATION; CENTROSOME; ABROGATE; INVASION; 3111 Biomedicine 
N1  -   
PP  -  
ER  -