TY  -  
T1  - Beyond good and evil: a putative continuum-sorting hypothesis for the functional role of proBDNF/BDNF-propeptide/mBDNF in antidepressant treatment 
SN  -  /  
UR  - http://hdl.handle.net/10138/303651 
T3  -  
A1  - Diniz, Cassiano R.A.F.; Casarotto, Plinio C.; Resstel, Leonardo; Samia, R.L. Joca 
A2  -  
PB  -  
Y1  - 2018 
LA  - eng 
AB  - Depression and posttraumatic stress disorder are assumed to be maladaptive responses to stress and antidepressants are thought to counteract such responses by increasing BDNF (brain-derived neurotrophic factor) levels. BDNF acts through TrkB (tropomyosin-related receptor kinase B) and plays a central role in neuroplasticity. In contrast, both precursor proBDNF and BDNF propeptide (another metabolic product from proBDNF cleavage) have a high affinity to p75 receptor (p75R) and usually convey apop... 
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KW  - 3112 Neurosciences; BDNF; proBDNF/BDNF-propeptide; stress; binary sorting hypothesis; depression; PTSD; P75 NEUROTROPHIN RECEPTOR; FACTOR MESSENGER-RNA; Depression; ELEMENT-BINDING PROTEIN; Stress; REGULATES HIPPOCAMPAL NEUROGENESIS; NERVE GROWTH-FACTOR; BDNF KNOCKOUT MICE; Continuum-sorting hypothesis; LONG-TERM DEPRESSION; MEDIAL PREFRONTAL CORTEX; FLUOXETINE TREATMENT INCREASES; DENTATE GYRUS 
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