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T1  - Binding specificities of human RNA-binding proteins toward structured and linear RNA sequences 
SN  -  /  
UR  - http://hdl.handle.net/10138/319234 
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A1  - Jolma, Arttu; Zhang, Jilin; Mondragon, Estefania; Morgunova, Ekaterina; Kivioja, Teemu; Laverty, Kaitlin U.; Yin, Yimeng; Zhu, Fangjie; Bourenkov, Gleb; Morris, Quaid; Hughes, Timothy R.; Maher III, Louis James; Taipale, Jussi 
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PB  -  
Y1  - 2020 
LA  - eng 
AB  - RNA-binding proteins (RBPs) regulate RNA metabolism at multiple levels by affecting splicing of nascent transcripts, RNA folding, base modification, transport, localization, translation, and stability. Despite their central role in RNA function, the RNA-binding specificities of most RBPs remain unknown or incompletely defined. To address this, we have assembled a genome-scale collection of RBPs and their RNA-binding domains (RBDs) and assessed their specificities using high-through-put RNA-SELEX... 
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KW  - AU-RICH ELEMENT; MESSENGER-RNA; RECOGNITION; DOMAIN; IDENTIFICATION; DECAY; SITE; 1182 Biochemistry, cell and molecular biology; 318 Medical biotechnology; 11832 Microbiology and virology; 1184 Genetics, developmental biology, physiology 
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