TY  -  
T1  - Biodistribution Analysis of Oncolytic Adenoviruses in Patient Autopsy Samples Reveals Vascular Transduction of Noninjected Tumors and Tissues 
SN  -  /  
UR  - http://hdl.handle.net/10138/305394 
T3  -  
A1  - Koski, Anniina; Bramante, Simona; Kipar, Anja; Oksanen, Minna; Juhila, Juuso; Vassilev, Lotta; Joensuu, Timo; Kanerva, Anna; Hemminki, Akseli 
A2  -  
PB  -  
Y1  - 2015 
LA  - eng 
AB  - In clinical trials with oncolytic adenoviruses, there has been no mortality associated with treatment vectors. Likewise, in the Advanced Therapy Access Program (ATAP), where 290 patients were treated with 10 different viruses, no vector-related mortality was observed. However, as the patient population who received adenovirus treatments in ATAP represented heavily pretreated patients, often with very advanced disease, some patients died relatively soon after receiving their virus treatment manda... 
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IS  -  
SP  -  
OP  -  
KW  - REFRACTORY SOLID TUMORS; I CLINICAL-TRIAL; CANCER-PATIENTS; PHASE-I; GM-CSF; REPLICATING ADENOVIRUS; OVARIAN-CANCER; IMMUNOTHERAPY; CHEMOTHERAPY; ONYX-015; 3122 Cancers; 3111 Biomedicine 
N1  -   
PP  -  
ER  -