TY  -  
T1  - Biopharmaceutics of Topical Ophthalmic Suspensions : Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin 
SN  -  /  
UR  - http://hdl.handle.net/10138/330141 
T3  -  
A1  - Toropainen, Elisa; Fraser-Miller, Sara J.; Novakovic, Dunja; Del Amo, Eva M.; Vellonen, Kati-Sisko; Ruponen, Marika; Viitala, Tapani; Korhonen, Ossi; Auriola, Seppo; Hellinen, Laura; Reinisalo, Mika; Tengvall, Unni; Choi, Stephanie; Absar, Mohammad; Strachan, Clare; Urtti, Arto 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - Eye drops of poorly soluble drugs are frequently formulated as suspensions. Bioavailability of suspended drug depends on the retention and dissolution of drug particles in the tear fluid, but these factors are still poorly understood. We investigated seven ocular indomethacin suspensions (experimental suspensions with two particle sizes and three viscosities, one commercial suspension) in physical and biological tests. The median particle size (d(50)) categories of the experimental suspensions w... 
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KW  - ocular absorption; indomethacin; suspension; bioequivalence; dissolution; particle size; viscosity; QUANTITATIVE-EVALUATION; SYSTEMIC ABSORPTION; BIOAVAILABILITY; CORNEAL; PILOCARPINE; VEHICLES; RABBITS; IMPACT; 317 Pharmacy 
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