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T1  - Bisphosphonate treatment in children with osteogenesis imperfecta : Benefits and concerns 
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UR  - http://hdl.handle.net/10138/228184; URN:ISBN:978-951-51-3834-7 
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A1  - Vuorimies, Ilkka 
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PB  - Helsingin yliopisto 
Y1  - 2017 
LA  - en 
AB  - Osteogenesis imperfecta is an inherited disorder of connective tissue characterized by bone fragility and low bone mass. It is caused by quantitatively or structurally abnormal type I collagen. Bisphosphonates, a group of anti-resorptive drugs, are commonly used as a medical therapy in children with osteogenesis imperfecta. A large number of studies have demonstrated their beneficial effects on bone mass and density. Much of their effects, especially long-term effects, in growing children remain... 
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