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T1  - Blood Leukocyte Signaling Pathways as Predictors of Severity of Acute Pancreatitis 
SN  -  /  
UR  - http://hdl.handle.net/10138/333899 
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A1  - Turunen, Antti; Kuuliala, Antti; Mustonen, Harri; Puolakkainen, Pauli; Kylänpää, Leena; Kuuliala, Krista 
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PB  -  
Y1  - 2021 
LA  - eng 
AB  - Objectives Clinical practice lacks biomarkers to predict the severity of acute pancreatitis (AP). We studied if intracellular signaling of circulating leukocytes could predict persistent organ dysfunction (OD) and secondary infections in AP. Methods A venous blood sample was taken from 174 patients with AP 72 hours or less from onset of symptoms and 31 healthy controls. Phosphorylation levels (p) of appropriately stimulated signal transducer and activator of transcription 1 (STAT1), STAT6, nucle... 
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KW  - pancreatitis; prognosis; blood; leukocytes; signal transduction; flow cytometry; NF-KAPPA-B; ORGAN FAILURE; INFLAMMATION; DYSFUNCTION; SEPSIS; STAT3; ASSOCIATION; ACTIVATION; TOLERANCE; THERAPIES; 3121 General medicine, internal medicine and other clinical medicine; 3126 Surgery, anesthesiology, intensive care, radiology 
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