TY  -  
T1  - Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology 
SN  -  /  
UR  - http://hdl.handle.net/10138/178992 
T3  -  
A1  - Szibor, Marten; Dhandapani, Praveen K.; Dufour, Eric; Holmstrom, Kira M.; Zhuang, Yuan; Salwig, Isabelle; Wittig, Ilka; Heidler, Juliana; Gizatullina, Zemfira; Gainutdinov, Timur; Fuchs, Helmut; Gailus-Durner, Valerie; de Angelis, Martin Hrabe; Nandania, Jatin; Velagapudi, Vidya; Wietelmann, Astrid; Rustin, Pierre; Gellerich, Frank N.; Jacobs, Howard T.; Braun, Thomas; German Mouse Clinic Consortium 
A2  -  
PB  -  
Y1  - 2017 
LA  - eng 
AB  - Plants and many lower organisms, but not mammals, express alternative oxidases (AOXs) that branch the mitochondrial respiratory chain, transferring electrons directly from ubiquinol to oxygen without proton pumping. Thus, they maintain electron flow under conditions when the classical respiratory chain is impaired, limiting excess production of oxygen radicals and supporting redox and metabolic homeostasis. AOX from Ciona intestinalis has been used to study and mitigate mitochondrial impairments... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - Mitochondria; Mitochondrial disease; Respiratory chain; Alternative oxidase; ALTERNATIVE-OXIDASE; NATIVE ELECTROPHORESIS; PROTEIN COMPLEXES; ACUTE LETHALITY; HUMAN-CELLS; MICE; MITOCHONDRIA; DROSOPHILA; DEFECTS; DEFICIENCY; 1182 Biochemistry, cell and molecular biology; 3111 Biomedicine 
N1  -   
PP  -  
ER  -