TY  -  
T1  - CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity 
SN  -  /  
UR  - http://hdl.handle.net/10138/331207 
T3  -  
A1  - Filppu, Pauliina; Ramanathan, Jayendrakishore Tanjore; Granberg, Kirsi J.; Gucciardo, Erika; Haapasalo, Hannu; Lehti, Kaisa; Nykter, Matti; Le Joncour, Vadim; Laakkonen, Pirjo 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - Glioma stem cells (GSCs) drive propagation and therapeutic resistance of glioblastomas, the most aggressive diffuse brain tumors. However, the molecular mechanisms that maintain the stemness and promote therapy resistance remain poorly understood. Here we report CD109/STAT3 axis as crucial for the maintenance of stemness and tumorigenicity of GSCs and as a mediator of chemoresistance. Mechanistically, CD109 physically interacts with glycoprotein 130 to promote activation of the IL-6/STAT3 pathwa... 
VO  -  
IS  -  
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OP  -  
KW  - GENE-EXPRESSION; NERVOUS-SYSTEM; CANCER; CD109; REVEALS; SURFACE; TUMORS; HYBRIDIZATION; ABNORMALITIES; INTERLEUKIN-6; 3111 Biomedicine; 1182 Biochemistry, cell and molecular biology 
N1  -   
PP  -  
ER  -