TY  -  
T1  - Cancer-Targeted Oncolytic Adenoviruses for Modulation of the Immune System 
SN  -  /  
UR  - http://hdl.handle.net/10138/321632 
T3  -  
A1  - Cerullo, Vincenzo; Capasso, Cristian; Vähä-Koskela, Markus; Hemminki, Otto; Hemminki, Akseli 
A2  -  
PB  -  
Y1  - 2018 
LA  - eng 
AB  - Adenovirus is one of the most commonly used vectors for gene therapy and it is the first approved virus-derived drug for treatment of cancer. As an oncolytic agent, it can induce lysis of infected cells, but it can also engage the immune system, promoting activation and maturation of antigen-presenting cells (APCs). In essence, oncolysis combined with the associated immunostimulatory actions result in a "personalized in situ vaccine" for each patient. In order to take full advantage of these fea... 
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KW  - Oncolytic adenovirus; gene therapy; innate immune system; adaptive immune system; pattern recognition receptors; armed oncolytic adenovirus; toll-like receptors; PHASE-I TRIAL; BETA GENE-THERAPY; NOD-LIKE RECEPTORS; REPLICATION-SELECTIVE ADENOVIRUS; METASTATIC PLEURAL EFFUSIONS; HELPER-DEPENDENT ADENOVIRUS; REFRACTORY SOLID TUMORS; T-CELL-ACTIVATION; GM-CSF; INTRATUMORAL INJECTION; 3111 Biomedicine; 317 Pharmacy 
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