TY - T1 - Candidate single nucleotide polymorphisms and thromboembolism in acute lymphoblastic leukemia - A NOPHO ALL2008 study SN - / UR - http://hdl.handle.net/10138/323892 T3 - A1 - Jarvis, Kirsten Brunsvig; LeBlanc, Marissa; Tulstrup, Morten; Nielsen, Rikke Linnemann; Albertsen, Birgitte Klug; Gupta, Ramneek; Huttunen, Pasi; Jonsson, Olafur Gisli; Rank, Cecilie Utke; Ranta, Susanna; Ruud, Ellen; Saks, Kadri; Trakymiene, Sonata Saulyte; Tuckuviene, Ruta; Schmiegelow, Kjeld A2 - PB - Y1 - 2019 LA - eng AB - Introduction: Thromboembolism is a serious toxicity of acute lymphoblastic leukemia treatment, and contributes to substantial morbidity and mortality. Several single nucleotide polymorphisms have been associated with thromboembolism in the general population; however, their impact in patients with acute lymphoblastic leukemia, particularly in children, remains uncertain. Materials and methods: We collected constitutional DNA and prospectively registered thromboembolic events in 1252 patients, 1-... VO - IS - SP - OP - KW - Thromboembolism; Single nucleotide polymorphisms; Acute lymphoblastic leukemia; INCIDENT VENOUS THROMBOEMBOLISM; DEVELOPMENTAL HEMOSTASIS; RISK-FACTORS; BLOOD-GROUP; CHILDREN; FIBRINOGEN; THROMBOSIS; METAANALYSIS; ASSOCIATION; VARIANTS; 3121 General medicine, internal medicine and other clinical medicine N1 - PP - ER -