TY - T1 - Cardiac fibrosis in myocardial infarction - from repair and remodeling to regeneration SN - / UR - http://hdl.handle.net/10138/166517 T3 - A1 - Talman, Virpi; Ruskoaho, Heikki Juhani A2 - PB - Y1 - 2016 LA - eng AB - Ischemic cell death during a myocardial infarction leads to a multiphase reparative response in which the damaged tissue is replaced with a fibrotic scar produced by fibroblasts and myofibroblasts. This also induces geometrical, biomechanical, and biochemical changes in the uninjured ventricular wall eliciting a reactive remodeling process that includes interstitial and perivascular fibrosis. Although the initial reparative fibrosis is crucial for preventing rupture of the ventricular wall, an e... VO - IS - SP - OP - KW - 317 Pharmacy N1 - PP - ER -