TY - T1 - Causes and Consequences of Hypertriglyceridemia SN - / UR - http://hdl.handle.net/10138/316278 T3 - A1 - Packard, Chris J.; Boren, Jan; Taskinen, Marja-Riitta A2 - PB - Y1 - 2020 LA - eng AB - Elevations in plasma triglyceride are the result of overproduction and impaired clearance of triglyceride-rich lipoproteins-very low-density lipoproteins (VLDL) and chylomicrons. Hypertriglyceridemia is characterized by an accumulation in the circulation of large VLDL-VLDL1-and its lipolytic products, and throughout the VLDL-LDL delipidation cascade perturbations occur that give rise to increased concentrations of remnant lipoproteins and small, dense low-density lipoprotein (LDL). The elevated ... VO - IS - SP - OP - KW - lipid; metabolism; VLDL; chylomicron; apoB; LOW-DENSITY-LIPOPROTEIN; TRIGLYCERIDE-RICH LIPOPROTEINS; APOLIPOPROTEIN-B METABOLISM; ATHEROSCLEROTIC CARDIOVASCULAR-DISEASE; PLASMA TRIGLYCERIDE; C-III; POSTPRANDIAL HYPERTRIGLYCERIDEMIA; APO-B-100 KINETICS; VLDL TRIGLYCERIDE; FATTY-ACIDS; 3121 General medicine, internal medicine and other clinical medicine N1 - PP - ER -