TY - T1 - Cellular Internalization-Induced Aggregation of Porous Silicon Nanoparticles for Ultrasound Imaging and Protein-Mediated Protection of Stem Cells SN - / UR - http://hdl.handle.net/10138/327363 T3 - A1 - Qi, Shengcai; Zhang, Pengfei; Ma, Ming; Yao, Minghua; Wu, Jinjin; Mäkilä, Ermei; Salonen, Jarno; Ruskoaho, Heikki; Xu, Yuanzhi; Santos, Helder A.; Zhang, Hongbo A2 - PB - Y1 - 2019 LA - eng AB - Nanotechnology employs multifunctional engineered materials in the nanoscale range that provides many opportunities for translational stem cell research and therapy. Here, a cell-penetrating peptide (virus-1 transactivator of transcription)-conjugated, porous silicon nanoparticle (TPSi NP) loaded with the Wnt3a protein to increase both the cell survival rate and the delivery precision of stem cell transplantation via a combinational theranostic strategy is presented. The TPSi NP with a pore size... VO - IS - SP - OP - KW - cell labeling; cell protection; drug delivery; porous silicon; ultrasound imaging; DRUG-DELIVERY; CONTRAST AGENT; THERAPY; BIOCOMPATIBILITY; SUSCEPTIBILITY; MICROBUBBLES; SIZE; 317 Pharmacy; 116 Chemical sciences; 221 Nano-technology; 114 Physical sciences N1 - PP - ER -