TY  -  
T1  - Cerebral Dopamine Neurotrophic Factor Is Essential for Enteric Neuronal Development, Maintenance and Regulation of Gastrointestinal Transit 
SN  -  /  
UR  - http://hdl.handle.net/10138/327712 
T3  -  
A1  - Chalazonitis, Alcmène; Li, ZhiShan; Pham, Tuan D.; Chen, Jason; Rao, Meenakshi; Lindholm, Päivi; Saarma, Mart; Lindahl, Maria; Gershon, Michael D. 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Abstract Cerebral dopamine neurotrophic factor (CDNF) is expressed in the brain and is neuroprotective. We have previously shown that CDNF is also expressed in the bowel and that its absence leads to degeneration and autophagy in the enteric nervous system (ENS), particularly in the submucosal plexus. We now demonstrate that enteric CDNF immunoreactivity is restricted to neurons (submucosal > myenteric) and is not seen in glia, interstitial cells of Cajal, or smooth muscle. Expression of CDNF, m... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - 3124 Neurology and psychiatry; Enteric nervous system; submucosal plexus; dopaminergic neurons; bone morphogenetic protein-4; serotonin; glial cell line derived neurotrophic factor; NERVOUS-SYSTEM; SEROTONIN TRANSPORTER; ALPHA-SYNUCLEIN; MICE LACKING; IN-VITRO; SUBMUCOSAL GANGLIA; FETAL-RAT GUT; enteric nervous system; CREST-DERIVED PRECURSORS; NEURAL CREST; PARKINSONS-DISEASE 
N1  -   
PP  -  
ER  -