TY  -  
T1  - Cleavage of the urokinase receptor (uPAR) on oral cancer cells : regulation by transforming growth factor - beta 1 (TGF-beta 1) and potential effects on migration and invasion 
SN  -  /  
UR  - http://hdl.handle.net/10138/190715 
T3  -  
A1  - Magnussen, Synnove Norvoll; Hadler-Olsen, Elin; Costea, Daniela Elena; Berg, Eli; Jacobsen, Cristiane Cavalcanti; Mortensen, Bente; Salo, Tuula; Martinez-Zubiaurre, Inigo; Winberg, Jan-Olof; Uhlin-Hansen, Lars; Svineng, Gunbjorg 
A2  -  
PB  -  
Y1  - 2017 
LA  - eng 
AB  - Background: Urokinase plasminogen activator (uPA) receptor (uPAR) is up-regulated at the invasive tumour front of human oral squamous cell carcinoma (OSCC), indicating a role for uPAR in tumour progression. We previously observed elevated expression of uPAR at the tumour-stroma interface in a mouse model for OSCC, which was associated with increased proteolytic activity. The tumour microenvironment regulated uPAR expression, as well as its glycosylation and cleavage. Both full-length- and cleave... 
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KW  - Urokinase plasminogen activator receptor (uPAR); Urokinase receptor; Transforming growth factor-beta1 (TGF-beta 1); Plasminogen; Plasmin; Cancer; Cell migration; Urokinase; Invasion; PLASMINOGEN-ACTIVATOR RECEPTOR; EPITHELIAL-MESENCHYMAL TRANSITION; LIGAND-BINDING DOMAIN; SMOOTH-MUSCLE-CELLS; BREAST-CANCER; TGF-BETA; IN-VITRO; MYOFIBROBLAST DIFFERENTIATION; TUMOR MICROENVIRONMENT; SOLUBLE RECEPTOR; 3122 Cancers 
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