TY  -  
T1  - Clinical Studies on Drug-Drug Interactions Involving Metabolism and Transport : Methodology, Pitfalls, and Interpretation 
SN  -  /  
UR  - http://hdl.handle.net/10138/302836 
T3  -  
A1  - Tornio, Aleksi; Filppula, Anne M.; Niemi, Mikko; Backman, Janne T. 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - Many drug-drug interactions (DDIs) are based on alterations of the plasma concentrations of a victim drug due to another drug causing inhibition and/or induction of the metabolism or transporter-mediated disposition of the victim drug. In the worst case, such interactions cause more than tenfold increases or decreases in victim drug exposure, with potentially life-threatening consequences. There has been tremendous progress in the predictability and modeling of DDIs. Accordingly, the combination... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - TIME-DEPENDENT PHARMACOKINETICS; PLASMA-CONCENTRATIONS; ROSUVASTATIN PHARMACOKINETICS; INTERACTION ASSESSMENTS; ENDOGENOUS BIOMARKERS; MARKEDLY DECREASES; GRAPEFRUIT JUICE; GENEVA COCKTAIL; CYTOCHROME-P450; INHIBITION; 317 Pharmacy; 3111 Biomedicine 
N1  -   
PP  -  
ER  -