TY  -  
T1  - Clinical research of dexmedetomidine in healthy volunteers 
SN  -  /  
UR  - URN:NBN:fi-fe201801151376; http://hdl.handle.net/10138/199531 
T3  -  
A1  - Bäckström, Mia 
A2  -  
PB  - Helsingfors universitet 
Y1  - 2017 
LA  - eng 
AB  - Background: 
Dexmedetomdine is a α2-adrenergic receptor agonist, which by binding to the α2-adrenergic receptor in the sympathetic nervous system exhibits sedative effect. Additionally, it has an analgesic and anxiolytic effect. Dexmedetomidine is registered as a sedative for use in the intensive care unit and in USA, additionally, in surgical settings. The study was conducted to characterize the pharmacokinetics in healthy volunteers through pharmacokinetic analysis methods.

Methods: 
The clin... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - dexmedetomidine; pharmacokinetics; population modeling; nonlinear mixed effects model; α2-agonist; dexmedetomidine; Biofarmaci; Biopharmacy; Biofarmasia 
N1  -   
PP  -  
ER  -