TY  -  
T1  - Clopidogrel but Not Prasugrel Significantly Inhibits the CYP2C8-Mediated Metabolism of Montelukast in Humans. 
SN  -  /  
UR  - http://hdl.handle.net/10138/243764 
T3  -  
A1  - Itkonen, Matti K.; Tornio, Aleksi; Filppula, Anne M.; Neuvonen, Mikko; Neuvonen, Pertti J.; Niemi, Mikko; Backman, Janne T. 
A2  -  
PB  -  
Y1  - 2018 
LA  - eng 
AB  - The oxidation of montelukast is mainly mediated by cytochrome P450 (CYP) 2C8, but other mechanisms may contribute to its disposition. In healthy volunteers, we investigated the effects of two widely used P2Y(12) inhibitors on montelukast pharmacokinetics. Clopidogrel (300mg on day 1 and 75mg on day 2) increased the area under the plasma concentration-time curve (AUC) of montelukast 2.0-fold (90% confidence interval (CI) 1.72-2.28, P <0.001) and decreased the M6:montelukast AUC(0-7h) ratio to 45%... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - ACUTE CORONARY SYNDROMES; CYP2C8 SUBSTRATE PIOGLITAZONE; DRUG-DRUG INTERACTIONS; GEMFIBROZIL; LEUKOTRIENE-RECEPTOR ANTAGONIST; MARKEDLY INCREASES; PHARMACOKINETICS; PLASMA-CONCENTRATIONS; 3121 General medicine, internal medicine and other clinical medicine 
N1  -   
PP  -  
ER  -