TY  -  
T1  - Closed Or Open after Source Control Laparotomy for Severe Complicated Intra-Abdominal Sepsis (the COOL trial) : study protocol for a randomized controlled trial 
SN  -  /  
UR  - http://hdl.handle.net/10138/237064 
T3  -  
A1  - Kirkpatrick, Andrew W.; Coccolini, Federico; Ansaloni, Luca; Roberts, Derek J.; Tolonen, Matti; McKee, Jessica L.; Leppaniemi, Ari; Faris, Peter; Doig, Christopher J.; Catena, Fausto; Fabian, Timothy; Jenne, Craig N.; Chiara, Osvaldo; Kubes, Paul; Manns, Braden; Kluger, Yoram; Fraga, Gustavo P.; Pereira, Bruno M.; Diaz, Jose J.; Sugrue, Michael; Moore, Ernest E.; Ren, Jianan; Ball, Chad G.; Coimbra, Raul; Balogh, Zsolt J.; Abu-Zidan, Fikri M.; Dixon, Elijah; Biffl, Walter; MacLean, Anthony; Ball, Ian; Drover, John; McBeth, Paul B.; Posadas-Calleja, Juan G.; Parry, Neil G.; Di Saverio, Salomone; Ordonez, Carlos A.; Xiao, Jimmy; Sartelli, Massimo 
A2  -  
PB  -  
Y1  - 2018 
LA  - eng 
AB  - Background: Severe complicated intra-abdominal sepsis (SCIAS) has an increasing incidence with mortality rates over 80% in some settings. Mortality typically results from disruption of the gastrointestinal tract, progressive and selfperpetuating bio-mediator generation, systemic inflammation, and multiple organ failure. Principles of treatment include early antibiotic administration and operative source control. A further therapeutic option may be open abdomen (OA) management with active negativ... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - Intra-peritoneal sepsis; Septic shock; Peritonitis; Open-abdomen; Multiple organ dysfunction; Laparotomy; Randomized trial; Bio-mediators; ABDOMINAL COMPARTMENT SYNDROME; MULTIPLE ORGAN DYSFUNCTION; DAMAGE-CONTROL LAPAROTOMY; SEVERE SECONDARY PERITONITIS; PRESSURE WOUND THERAPY; INTENSIVE-CARE-UNIT; SEPTIC SHOCK; OPEN ABDOMEN; CLINICAL-PRACTICE; CRITICALLY-ILL; 3126 Surgery, anesthesiology, intensive care, radiology 
N1  -   
PP  -  
ER  -