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T1  - Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance 
SN  -  /  
UR  - http://hdl.handle.net/10138/334455 
T3  -  
A1  - Pietilä, Elina A.; Gonzalez-Molina, Jordi; Moyano-Galceran, Lidia; Jamalzadeh, Sanaz; Zhang, Kaiyang; Lehtinen, Laura; Turunen, S. Pauliina; Martins, Tomas A.; Gultekin, Okan; Lamminen, Tarja; Kaipio, Katja; Joneborg, Ulrika; Hynninen, Johanna; Hietanen, Sakari; Grenman, Seija; Lehtonen, Rainer; Hautaniemi, Sampsa; Carpen, Olli; Carlson, Joseph W.; Lehti, Kaisa 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - Due to its dynamic nature, the evolution of cancer cell-extracellular matrix (ECM) crosstalk, critically affecting metastasis and treatment resistance, remains elusive. Our results show that platinum-chemotherapy itself enhances resistance by progressively changing the cancer cell-intrinsic adhesion signaling and cell-surrounding ECM. Examining ovarian high-grade serous carcinoma (HGSC) transcriptome and histology, we describe the fibrotic ECM heterogeneity at primary tumors and distinct metasta... 
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OP  -  
KW  - EXTRACELLULAR-MATRIX; COLLAGEN-VI; METASTASIS; RESISTANCE; APOPTOSIS; INVASION; STROMA; ACTIN; CELLS; 3122 Cancers; 3123 Gynaecology and paediatrics 
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ER  -