TY - T1 - Cobalt nanoparticles trigger ferroptosis-like cell death (oxytosis) in neuronal cells : Potential implications for neurodegenerative disease SN - / UR - http://hdl.handle.net/10138/317347 T3 - A1 - Gupta, Govind; Gliga, Anda; Hedberg, Jonas; Serra, Angela; Greco, Dario; Odnevall Wallinder, Inger; Fadeel, Bengt A2 - PB - Y1 - 2020 LA - eng AB - Abstract The neurotoxicity of hard metal-based nanoparticles (NPs) remains poorly understood. Here, we deployed the human neuroblastoma cell line SH-SY5Y differentiated or not into dopaminergic- and cholinergic-like neurons to study the impact of tungsten carbide (WC) NPs, WC NPs sintered with cobalt (Co), or Co NPs versus soluble CoCl2. Co NPs and Co salt triggered a dose-dependent cytotoxicity with an increase in cytosolic calcium, lipid peroxidation, and depletion of glutathione (GSH). Co NPs... VO - IS - SP - OP - KW - 1182 Biochemistry, cell and molecular biology; cobalt; ferroptosis; hard metal; nanoparticles; neurodegeneration; oxytosis; OXIDATIVE STRESS; MECHANISM; PARTICLES; FORM; TOXICITY; GLUTATHIONE; BIOLOGY; METAL; INDUCED CYTOTOXICITY; HEALTH N1 - PP - ER -