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T1  - Cobalt nanoparticles trigger ferroptosis-like cell death (oxytosis) in neuronal cells : Potential implications for neurodegenerative disease 
SN  -  /  
UR  - http://hdl.handle.net/10138/317347 
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A1  - Gupta, Govind; Gliga, Anda; Hedberg, Jonas; Serra, Angela; Greco, Dario; Odnevall Wallinder, Inger; Fadeel, Bengt 
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PB  -  
Y1  - 2020 
LA  - eng 
AB  - Abstract The neurotoxicity of hard metal-based nanoparticles (NPs) remains poorly understood. Here, we deployed the human neuroblastoma cell line SH-SY5Y differentiated or not into dopaminergic- and cholinergic-like neurons to study the impact of tungsten carbide (WC) NPs, WC NPs sintered with cobalt (Co), or Co NPs versus soluble CoCl2. Co NPs and Co salt triggered a dose-dependent cytotoxicity with an increase in cytosolic calcium, lipid peroxidation, and depletion of glutathione (GSH). Co NPs... 
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KW  - 1182 Biochemistry, cell and molecular biology; cobalt; ferroptosis; hard metal; nanoparticles; neurodegeneration; oxytosis; OXIDATIVE STRESS; MECHANISM; PARTICLES; FORM; TOXICITY; GLUTATHIONE; BIOLOGY; METAL; INDUCED CYTOTOXICITY; HEALTH 
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