TY  -  
T1  - Cobalt-Catalyzed alpha-Arylation of Substituted alpha-Bromo alpha-Fluoro beta-Lactams with Diaryl Zinc Reagents : Generalization to Functionalized Bromo Derivatives 
SN  -  /  
UR  - http://hdl.handle.net/10138/335329 
T3  -  
A1  - Lorion, Melanie M.; Koch, Vanessa; Nieger, Martin; Chen, Hi-Yung; Lei, Aiwen; Bräse, Stefan; Cossy, Janine 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - A cobalt-catalyzed cross-coupling of alpha-bromo alpha-fluoro beta-lactams with diarylzinc or diallylzinc reagents is herein disclosed. The protocol proved to be general, chemoselective and operationally simple allowing the C4 functionalization of beta-lactams. The substrate scope was expanded to alpha-bromo lactams and amides, alpha-bromo lactones and esters as well asN- and O-containing heterocycles.... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - beta-lactam; bis(organo)zinc reagents; catalysis; cobalt; cross-coupling; CROSS-COUPLING REACTIONS; AMIDES; 116 Chemical sciences 
N1  -   
PP  -  
ER  -