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T1  - Colonic Gene Expression and Fecal Microbiota in Diarrhea-predominant Irritable Bowel Syndrome : Increased Toll-like Receptor 4 but Minimal Inflammation and no Response to Mesalazine 
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UR  - http://hdl.handle.net/10138/331753 
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A1  - Jalanka, Jonna; Lam, Ching; Bennett, Andrew; Hartikainen, Anna; Crispie, Fiona; Finnegan, Laura A.; Cotter, Paul D.; Spiller, Robin 
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Y1  - 2021 
LA  - eng 
AB  - Background/Aims Diarrhea-predominant irritable bowel syndrome (IBS-D) has been previously associated with evidence of immune activation and altered microbiota. Our aim is to assess the effect of the anti-inflammatory agent, mesalazine, on inflammatory gene expression and microbiota composition in IBS-D. Methods We studied a subset of patients (n = 43) from a previously published 12-week radomized placebo-controlled trial of mesalazine. Mucosal biopsies were assessed by immunohistochemistry and r... 
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KW  - Gene expression; Irritable bowel syndrome; Mesalazine; Microbiota; Toll-like receptor 4; 5-AMINOSALICYLIC ACID; GASTROINTESTINAL MOTILITY; PROTEASE ACTIVITY; GUT MICROBIOTA; IBS; PERMEABILITY; ACTIVATION; BRADYKININ; BACTERIAL; SEVERITY; 3121 General medicine, internal medicine and other clinical medicine; 3112 Neurosciences; 3124 Neurology and psychiatry 
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