TY - T1 - Colonic Gene Expression and Fecal Microbiota in Diarrhea-predominant Irritable Bowel Syndrome : Increased Toll-like Receptor 4 but Minimal Inflammation and no Response to Mesalazine SN - / UR - http://hdl.handle.net/10138/331753 T3 - A1 - Jalanka, Jonna; Lam, Ching; Bennett, Andrew; Hartikainen, Anna; Crispie, Fiona; Finnegan, Laura A.; Cotter, Paul D.; Spiller, Robin A2 - PB - Y1 - 2021 LA - eng AB - Background/Aims Diarrhea-predominant irritable bowel syndrome (IBS-D) has been previously associated with evidence of immune activation and altered microbiota. Our aim is to assess the effect of the anti-inflammatory agent, mesalazine, on inflammatory gene expression and microbiota composition in IBS-D. Methods We studied a subset of patients (n = 43) from a previously published 12-week radomized placebo-controlled trial of mesalazine. Mucosal biopsies were assessed by immunohistochemistry and r... VO - IS - SP - OP - KW - Gene expression; Irritable bowel syndrome; Mesalazine; Microbiota; Toll-like receptor 4; 5-AMINOSALICYLIC ACID; GASTROINTESTINAL MOTILITY; PROTEASE ACTIVITY; GUT MICROBIOTA; IBS; PERMEABILITY; ACTIVATION; BRADYKININ; BACTERIAL; SEVERITY; 3121 General medicine, internal medicine and other clinical medicine; 3112 Neurosciences; 3124 Neurology and psychiatry N1 - PP - ER -