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T1  - Combined Analysis of Variation in Core, Accessory and Regulatory Genome Regions Provides a Super-Resolution View into the Evolution of Bacterial Populations 
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UR  - http://hdl.handle.net/10138/169214 
T3  -  
A1  - McNally, Alan; Oren, Yaara; Kelly, Darren; Pascoe, Ben; Dunn, Steven; Sreecharan, Tristan; Vehkala, Minna; Välimäki, Niko; Prentice, Michael B.; Ashour, Amgad; Avram, Oren; Pupko, Tal; Dobrindt, Ulrich; Literak, Ivan; Guenther, Sebastian; Schaufler, Katharina; Wieler, Lothar H.; Zong Zhiyong; Sheppard, Samuel K.; McInerney, James O.; Corander, Jukka 
A2  -  
PB  -  
Y1  - 2016 
LA  - eng 
AB  - The use of whole-genome phylogenetic analysis has revolutionized our understanding of the evolution and spread of many important bacterial pathogens due to the high resolution view it provides. However, the majority of such analyses do not consider the potential role of accessory genes when inferring evolutionary trajectories. Moreover, the recently discovered importance of the switching of gene regulatory elements suggests that an exhaustive analysis, combining information from core and accesso... 
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KW  - RESISTANT ESCHERICHIA-COLI; PHYLOGENETIC TREES; ST131 CLONE; OUTBREAK; ANNOTATION; DIVERSITY; EMERGENCE; PLASMIDS; 1184 Genetics, developmental biology, physiology 
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ER  -