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T1  - Combined comparative genomic hybridization and transcriptomic analyses of ovarian granulosa cell tumors point to novel candidate driver genes 
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UR  - http://hdl.handle.net/10138/164046 
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A1  - Caburet, Sandrine; Anttonen, Mikko; Todeschini, Anne-Laure; Unkila-Kallio, Leila; Mestivier, Denis; Butzow, Ralf; Veitia, Reiner A. 
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PB  -  
Y1  - 2015 
LA  - eng 
AB  - Background: Ovarian granulosa cell tumors (GCTs) are the most frequent sex cord-stromal tumors. Several studies have shown that a somatic mutation leading to a C134W substitution in the transcription factor FOXL2 appears in more than 95% of adult-type GCTs. Its pervasive presence suggests that FOXL2 is the main cancer driver gene. However, other mutations and genomic changes might also contribute to tumor formation and/or progression. Methods: We have performed a combined comparative genomic hyb... 
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KW  - Ovarian granulosa cell tumor; Driver genes; CGH; Transcriptomics; EPITHELIAL PROTEIN LOST; AAA-ATPASE NVL2; BREAST-CANCER; DOWN-REGULATION; FOXL2 MUTATION; DNA-DAMAGE; IN-VITRO; EXPRESSION; EPLIN; PROGRESSION; 3123 Gynaecology and paediatrics; 3122 Cancers; 3111 Biomedicine 
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