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T1  - Combined epithelial marker analysis of tumour budding in stage II colorectal cancer 
SN  -  /  
UR  - http://hdl.handle.net/10138/298535 
T3  -  
A1  - Slik, Khadija; Blom, Sami; Turkki, Riku; Välimäki, Katja; Kurki, Samu; Mustonen, Harri; Haglund, Caj; Carpén, Olli; Kallioniemi, Olli; Korkeila, Eija; Sundström, Jari; Pellinen, Teijo 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - Tumour budding predicts survival of stage II colorectal cancer (CRC) and has been suggested to be associated with epithelial-to-mesenchymal transition (EMT). However, the underlying molecular changes of tumour budding remain poorly understood. Here, we performed multiplex immunohistochemistry (mIHC) to phenotypically profile tumours using known EMT-associated markers: E-cadherin (adherence junctions), integrin beta 4 (ITGB4; basement membrane), ZO-1 (tight junctions), and pan-cytokeratin. A subp... 
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KW  - tumour budding; colorectal cancer; multiplex immunohistochemistry; digital pathology; integrin β4; epithelial-to-mesenchymal transition; prognostics; tumour budding; colorectal cancer; multiplex immunohistochemistry; digital pathology; integrin beta 4; epithelial-to-mesenchymal transition; prognostics; MESENCHYMAL TRANSITION; PROGNOSTIC MARKER; EXPRESSION; INTEGRIN; PROTEIN; RECOMMENDATIONS; ALPHA-6-BETA-4; CARCINOMAS; 3122 Cancers; 3111 Biomedicine; 114 Physical sciences 
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