TY - T1 - Comorbidity of substance misuse with anxiety-related and depressive disorders : a genetically informative population study of 3 million individuals in Sweden SN - / UR - http://hdl.handle.net/10138/321278 T3 - A1 - Virtanen, Suvi; Kuja-Halkola, Ralf; Mataix-Cols, David; Jayaram-Lindström, Nitya; D'Onofrio, Brian M.; Larsson, Henrik; Ruck, Christian; Suvisaari, Jaana; Lichtenstein, Paul; Latvala, Antti A2 - PB - Y1 - 2020 LA - eng AB - Background Causes of the comorbidity of substance misuse with anxiety-related and depressive disorders (anxiety/depression) remain poorly known. We estimated associations of substance misuse and anxiety/depression in the general population and tested them while accounting for genetic and shared environmental factors. Methods We studied individuals born in Sweden 1968–1997 (n = 2 996 398) with follow-up in nationwide register data for 1997–2013. To account for familial effects, stratified analyse... VO - IS - SP - OP - KW - 3124 Neurology and psychiatry; 515 Psychology; Alcohol; anxiety; cohort; depression; drug; family study; genetic; substance use; twins; ALCOHOL-USE DISORDERS; DRUG-USE DISORDERS; POSTTRAUMATIC-STRESS-DISORDER; NATIONAL EPIDEMIOLOGIC SURVEY; ENVIRONMENTAL RISK-FACTORS; DSM-IV MOOD; PSYCHIATRIC-DISORDERS; MENTAL-HEALTH; PREVALENCE; LIFETIME N1 - PP - ER -