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T1  - Comparison of Serum and Urinary 5-Hydroxyindoleacetic Acid as Biomarker for Neuroendocrine Neoplasms 
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UR  - http://hdl.handle.net/10138/335062 
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A1  - Becker, Anna; Schalin-Jäntti, Camilla; Itkonen, Outi 
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Y1  - 2021 
LA  - eng 
AB  - Context: Patients with serotonin-secreting neuroendocrine neoplasms (NENs) have increased serum 5-hydroxyindoleacetic acid (5HIAA) concentrations. Serum 5HIAA thus serves as a biomarker in NEN. Objective: To evaluate an improved tandem mass spectrometric serum 5HIAA assay for diagnosis and follow-up of NEN in a clinical cohort. Design: A retrospective study during 2016-2018 at the Diagnostic Center and Department of Endocrinology at Helsinki University Hospital, Finland. Methods: Detailed patien... 
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KW  - neuroendocrine neoplasms; 5-hydroxyindoleacetic acid; LC-MS/MS; serum; urine; LIQUID-CHROMATOGRAPHY; 5-HYDROXY-3-INDOLEACETIC ACID; ACETIC-ACID; 5-HIAA; ASSAY; METABOLITES; EXTRACTION; SEROTONIN; DIAGNOSIS; CONSENSUS; 3121 General medicine, internal medicine and other clinical medicine 
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