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T1  - Comparison of melibiose and trehalose as stabilising excipients for spray-dried beta-galactosidase formulations 
SN  -  /  
UR  - http://hdl.handle.net/10138/300199 
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A1  - Lipiäinen, Tiina; Räikkönen, Heikki; Kolu, Anna-Maija; Peltoniemi, Marikki; Juppo, Anne 
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PB  -  
Y1  - 2018 
LA  - eng 
AB  - Spray-dried protein formulations commonly require stabilising excipients to prevent protein degradation during processing and storage, and trehalose has been commonly used. The purpose of this work was to evaluate melibiose in spray-dried protein formulations in comparison to trehalose. The protein-activity-preserving efficacy, process behaviour and storage stability were studied. Spray drying of beta-galactosidase was carried out using different process temperature, drying air flow and feed liq... 
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KW  - 317 Pharmacy; Spray drying; Protein stability; Excipients; Melibiose; Trehalose 
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ER  -