TY  -  
T1  - Compounds that modulate AMPK activity and hepatic steatosis impact the biosynthesis of microRNAs required to maintain lipid homeostasis in hepatocytes 
SN  -  /  
UR  - http://hdl.handle.net/10138/314772 
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A1  - Latorre, Jèssica; Ortega, Francisco J.; Liñares-Pose, Laura; Moreno-Navarrete, José M.; Lluch, Aina; Comas, Ferran; Oliveras-Cañellas, Núria; Ricart, Wifredo; Höring, Marcus; Zhou, You; Liebisch, Gerhard; Nidhina Haridas, P.A.; Olkkonen, Vesa M.; López, Miguel; Fernández-Real, José M. 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Background: While the impact of metformin in hepatocytes leads to fatty acid (FA) oxidation and decreased lipogenesis, hepatic microRNAs (miRNAs) have been associated with fat overload and impaired metabolism, contributing to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Methods: We investigated the expression of hundreds of miRNAs in primary hepatocytes challenged by compounds modulating steatosis, palmitic acid and compound C (as inducers), and metformin (as an inhibitor). The... 
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IS  -  
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KW  - 3111 Biomedicine; MicroRNAs; AMPK; Hepatocytes; Fatty acid homeostasis; Steatosis; METFORMIN; NAFLD; CHOLESTEROL; DE-NOVO LIPOGENESIS; FATTY LIVER-DISEASE; TRANSCRIPTION; ATHEROSCLEROSIS; METABOLISM; HIGH-THROUGHPUT QUANTIFICATION; MOLECULAR-MECHANISMS 
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ER  -