TY  -  
T1  - Computational Analysis of HLA-presentation of Non-synonymous Recipient Mismatches Indicates Effect on the Risk of Chronic Graft-vs.-Host Disease After Allogeneic HSCT 
SN  -  /  
UR  - http://hdl.handle.net/10138/305882 
T3  -  
A1  - Ritari, Jarmo; Hyvärinen, Kati; Koskela, Satu; Niittyvuopio, Riitta; Nihtinen, Anne; Salmenniemi, Urpu; Putkonen, Mervi; Volin, Liisa; Kwan, Tony; Pastinen, Tomi; Itälä-Remes, Maija; Partanen, Jukka 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - Genetic mismatches in protein coding genes between allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipient and donor can elicit an alloimmunity response via peptides presented by the recipient HLA receptors as minor histocompatibility antigens (mHAs). While the impact of individual mHAs on allo-HSCT outcome such as graft-vs.-host and graft-vs.-leukemia effects has been demonstrated, it is likely that established mHAs constitute only a small fraction of all immunogenic non-synony... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - whole-exome sequencing; HSCT; HLA; minor histocompatibility antigen; genomics; graft-vs.-host; MINOR HISTOCOMPATIBILITY ANTIGENS; ASSOCIATION; GENERATION; CELLS; GVHD; 3122 Cancers; 3111 Biomedicine; 1184 Genetics, developmental biology, physiology 
N1  -   
PP  -  
ER  -