TY  -  
T1  - Conservative management of retinoblastoma : Challenging orthodoxy without compromising the state of metastatic grace. "Alive, with good vision and no comorbidity" 
SN  -  /  
UR  - http://hdl.handle.net/10138/310388 
T3  -  
A1  - Munier, Francis L.; Beck-Popovic, Maja; Chantada, Guillermo L.; Cobrinik, David; Kivelä, Tero T.; Lohmann, Dietmar; Maeder, Philippe; Moll, Annette C.; Carcaboso, Angel Montero; Moulin, Alexandre; Schaiquevich, Paula; Bergin, Ciara; Dyson, Paul J.; Houghton, Susan; Puccinelli, Francesco; Vial, Yvan; Gaillard, Marie-Claire; Stathopoulos, Christina 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - Retinoblastoma is lethal by metastasis if left untreated, so the primary goal of therapy is to preserve life, with ocular survival, visual preservation and quality of life as secondary aims. Historically, enucleation was the first successful therapeutic approach to decrease mortality, followed over 100 years ago by the first eye salvage attempts with radiotherapy. This led to the empiric delineation of a window for conservative management subject to a "state of metastatic grace" never to be viol... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - Retinoblastoma; Treatment; Intra-arterial chemotherapy; Intravitreal chemotherapy; Intracameral chemotherapy; Complication; Metastasis; Liquid biopsy; OPHTHALMIC-ARTERY-CHEMOSURGERY; EXTERNAL-BEAM RADIOTHERAPY; RHEGMATOGENOUS RETINAL-DETACHMENT; OPTICAL COHERENCE TOMOGRAPHY; DIFFUSE INFILTRATING RETINOBLASTOMA; RADIATION-INDUCED CATARACTS; HIGH-RISK RETINOBLASTOMA; 2ND PRIMARY MALIGNANCIES; LONG-TERM SURVIVORS; QUALITY-OF-LIFE; 3125 Otorhinolaryngology, ophthalmology 
N1  -   
PP  -  
ER  -