TY - T1 - Contributions of µ- and κ-opioidergic systems to ethanol intake and addiction SN - / UR - URN:ISBN:978-951-51-5447-7; http://hdl.handle.net/10138/305335 T3 - A1 - Uhari-Väänänen, Johanna A2 - PB - Helsingin yliopisto Y1 - 2019 LA - eng AB - Ethanol use disorders affect a vast number of people worldwide. In some individuals, controlled ethanol intake can gradually progress via ethanol abuse into addiction, characterized by escalated, uncontrolled and compulsive ethanol seeking and intake despite its negative consequences. A negative emotional state is common when ethanol is not available. The relapsing nature of this chronic disease also makes it difficult to treat. As the clinical efficiency of the currently available pharmacothera... VO - IS - SP - OP - KW - farmakologia N1 - PP - ER -