TY  -  
T1  - Controlled Monofunctionalization of Molecular Spherical Nucleic Acids on a Buckminster Fullerene Core 
SN  -  /  
UR  - http://hdl.handle.net/10138/332748 
T3  -  
A1  - Gulumkar, Vijay; Äärelä, Antti; Moisio, Olli; Rahkila, Jani; Tähtinen, Ville; Leimu, Laura; Korsoff, Niko; Korhonen, Heidi; Poijärvi-Virta, Päivi; Mikkola, Satu; Nesati, Victor; Vuorimaa-Laukkanen, Elina; Viitala, Tapani; Yliperttula, Marjo; Roivainen, Anne; Virta, Pasi 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - An azide-functionalized 12-armed Buckminster fullerene has been monosubstituted in organic media with a substoichiometric amount of cyclooctyne-modified oligonucleo-tides. Exposing the intermediate products then to the same reaction (i. e., strain-promoted alkyne-azide cycloaddition, SPAAC) with an excess of slightly different oligonucleotide constituents in an aqueous medium yields molecularly defined monofunctionalized spherical nucleic acids (SNAs). This procedure offers a controlled synthesi... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - CELLULAR UPTAKE; CLICK CHEMISTRY; MECHANISM; AZIDES; 317 Pharmacy 
N1  -   
PP  -  
ER  -