TY  -  
T1  - Cooperation between Different CRISPR-Cas Types Enables Adaptation in an RNA-Targeting System 
SN  -  /  
UR  - http://hdl.handle.net/10138/330148 
T3  -  
A1  - Hoikkala, Ville; Ravantti, Janne; Diez-Villasenor, Cesar; Tiirola, Marja; Conrad, Rachel A.; McBride, Mark J.; Moineau, Sylvain; Sundberg, Lotta-Riina 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - CRISPR-Cas immune systems adapt to new threats by acquiring new spacers from invading nucleic acids such as phage genomes. However, some CRISPR-Cas loci lack genes necessary for spacer acquisition despite variation in spacer content between microbial strains. It has been suggested that such loci may use acquisition machinery from cooccurring CRISPR-Cas systems within the same strain. Here, following infection by a virulent phage with a double-stranded DNA (dsDNA) genome, we observed spacer acqui... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - CRISPR; adaptation; bacteriophages; coevolution; spacer acquisition; type II; type VI; 1184 Genetics, developmental biology, physiology 
N1  -   
PP  -  
ER  -