TY  -  
T1  - Coordinated control of adiposity and growth by anti-anabolic kinase ERK7 
SN  -  /  
UR  - http://hdl.handle.net/10138/326217 
T3  -  
A1  - Hasygar, Kiran; Deniz, Onur; Liu, Ying; Gullmets, Josef; Hynynen, Riikka; Ruhanen, Hanna; Kokki, Krista; Kakela, Reijo; Hietakangas, Ville 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - Energy storage and growth are coordinated in response to nutrient status of animals. How nutrient-regulated signaling pathways control these processes in vivo remains insufficiently understood. Here, we establish an atypical MAP kinase, ERK7, as an inhibitor of adiposity and growth in Drosophila. ERK7 mutant larvae display elevated triacylglycerol (TAG) stores and accelerated growth rate, while overexpressed ERK7 is sufficient to inhibit lipid storage and growth. ERK7 expression is elevated upon... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - growth; lipid metabolism; nutrient sensing; signaling; CELL-PROLIFERATION; FAT-BODY; DROSOPHILA; METABOLISM; ACTIVATION; STARVATION; AUTOPHAGY; MAPK15; PHOSPHORYLATION; CONTRIBUTES; 1182 Biochemistry, cell and molecular biology 
N1  -   
PP  -  
ER  -