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T1  - Cortical Excitability and Activation of TrkB Signaling During Rebound Slow Oscillations Are Critical for Rapid Antidepressant Responses 
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UR  - http://hdl.handle.net/10138/301593 
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A1  - Kohtala, Henrik Samuel; Theilmann, Wiebke; Rosenholm, Marko; Penna, Leena; Karabulut, Gulsum; Uusitalo, Salla; Järventausta, Kaija; Yli-Hankala, Arvi; Yalcin, Ipek; Matsui, Nobuaki; Wigren, Henna-Kaisa; Rantamäki, Tomi 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - Rapid antidepressant effects of ketamine become most evident when its psychotomimetic effects subside, but the neurobiological basis of this lag remains unclear. Laughing gas (N2O), another NMDA-R (N-methyl-d-aspartate receptor) blocker, has been reported to bring antidepressant effects rapidly upon drug discontinuation. We took advantage of the exceptional pharmacokinetic properties of N2O to investigate EEG (electroencephalogram) alterations and molecular determinants of antidepressant actions... 
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OP  -  
KW  - 3124 Neurology and psychiatry; 3111 Biomedicine; Rapid-acting antidepressant; Nitrous oxide; Ketamine; Cortical excitation; Electroencephalogram; Sedation; GLYCOGEN-SYNTHASE KINASE-3; NMDA RECEPTOR BLOCKADE; ELECTROCONVULSIVE-THERAPY; NEUROTROPHIN RECEPTOR; SLEEP-DEPRIVATION; PREFRONTAL CORTEX; NITROUS-OXIDE; DELTA-EEG; KETAMINE; STIMULATION 
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