TY - T1 - Critical-sized cartilage defects in the equine carpus SN - / UR - http://hdl.handle.net/10138/312138 T3 - A1 - Salonius, Eve; Rieppo, Lassi; Nissi, Mikko J.; Pulkkinen, Hertta J.; Brommer, Harold; Bruenott, Anne; Silvast, Tuomo S.; Van Weeren, P. Rene; Muhonen, Virpi; Brama, Pieter A. J.; Kiviranta, Ilkka A2 - PB - Y1 - 2019 LA - eng AB - Aim: The horse joint, due to its similarity with the human joint, is the ultimate model for translational articular cartilage repair studies. This study was designed to determine the critical size of cartilage defects in the equine carpus and serve as a benchmark for the evaluation of new cartilage treatment options. Material and Methods: Circular full-thickness cartilage defects with a diameter of 2, 4, and 8 mm were created in the left middle carpal joint and similar osteochondral (3.5 mm in d... VO - IS - SP - OP - KW - Animal model; cartilage repair; critical-sized defect; preclinical research; spontaneous repair; OSTEOCHONDRAL DEFECTS; ANIMAL-MODELS; REPAIR; BONE; TOMOGRAPHY; TISSUE; HORSE; 1182 Biochemistry, cell and molecular biology; 3126 Surgery, anesthesiology, intensive care, radiology N1 - PP - ER -