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T1  - Current Status and Future Prospects of C1 Domain Ligands as Drug Candidates 
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UR  - http://hdl.handle.net/10138/161200 
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A1  - Boije af Gennäs, Gustav; Talman, Virpi; Yli-Kauhaluoma, Jari; Tuominen, Raimo K.; Ekokoski, Elina 
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Y1  - 2011 
LA  - eng 
AB  - The second messenger diacylglycerol (DAG) plays a central role in the signal transduction of G-protein coupled receptors and receptor tyrosine kinases by binding to C1 domain of effector proteins. C1 domain was first identified in protein kinase C (PKC) which comprises a family of ten isoforms that play roles in diverse cellular processes such as proliferation, apoptosis and differentiation. Aberrant signaling through PKC isoforms and other C1 domain-containing proteins has been implicated in se... 
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KW  - Protein kinase C; C1 domain; drug discovery; cancer; Alzheimer's disease; bryostatins; ingenol-3-angelate; DAG-lactones; PROTEIN-KINASE-C; CONFORMATIONALLY CONSTRAINED ANALOGS; CHRONIC LYMPHOCYTIC-LEUKEMIA; ACTIVATOR-BINDING DOMAIN; PHORBOL ESTER RECEPTOR; CELLS IN-VITRO; NF-KAPPA-B; NEURONAL ELAV PROTEINS; LACTONES DAG-LACTONES; PROSTATE-CANCER CELLS; 317 Pharmacy 
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