TY  -  
T1  - Cyclin-dependent kinase 2 protects podocytes from apoptosis 
SN  -  /  
UR  - http://hdl.handle.net/10138/160991 
T3  -  
A1  - Saurus, Pauliina; Kuusela, Sara; Dumont, Vincent; Lehtonen, Eero; Fogarty, Christopher L.; Lassenius, Mariann I.; Forsblom, Carol; Lehto, Markku; Saleem, Moin A.; Groop, Per-Henrik; Lehtonen, Sanna 
A2  -  
PB  -  
Y1  - 2016 
LA  - eng 
AB  - Loss of podocytes is an early feature of diabetic nephropathy (DN) and predicts its progression. We found that treatment of podocytes with sera from normoalbuminuric type 1 diabetes patients with high lipopolysaccharide (LPS) activity, known to predict progression of DN, downregulated CDK2 (cyclin-dependent kinase 2). LPS-treatment of mice also reduced CDK2 expression. LPS-induced downregulation of CDK2 was prevented in vitro and in vivo by inhibiting the Toll-like receptor (TLR) pathway using i... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - AMINONUCLEOSIDE-INDUCED APOPTOSIS; DIABETIC-NEPHROPATHY; CELL-PROLIFERATION; IN-VIVO; DOWN-REGULATION; GROWTH-FACTOR; DNA-DAMAGE; FATTY RATS; S-PHASE; MICE; 3111 Biomedicine 
N1  -   
PP  -  
ER  -