TY  -  
T1  - Cytoskeletal Stability in the Auditory Organ In Vivo : RhoA Is Dispensable for Wound Healing but Essential for Hair Cell Development 
SN  -  /  
UR  - http://hdl.handle.net/10138/240084 
T3  -  
A1  - Anttonen, Tommi; Belevich, Ilya; Laos, Maarja; Herranen, Anni; Jokitalo, Eija; Brakebusch, Cord; Pirvola, Ulla 
A2  -  
PB  -  
Y1  - 2017 
LA  - eng 
AB  - Wound healing in the inner ear sensory epithelia is performed by the apical domains of supporting cells (SCs). Junctional F-actin belts of SCs are thin during development but become exceptionally thick during maturation. The functional significance of the thick belts is not fully understood. We have studied the role of F-actin belts during wound healing in the developing and adult cochlea of mice in vivo. We show that the thick belts serve as intracellular scaffolds that preserve the positions o... 
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OP  -  
KW  - Auditory; cytoskeleton; development; inner ear; RhoA; wound healing; INNER-EAR; APICAL CONSTRICTION; SUPPORTING CELLS; SINGLE-CELL; POLARITY; MOUSE; JUNCTIONS; COCHLEA; MORPHOGENESIS; ORGANIZATION; 3112 Neurosciences 
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ER  -