TY  -  
T1  - DLA class II risk haplotypes for autoimmune diseases in the bearded collie offer insight to autoimmunity signatures across dog breeds 
SN  -  /  
UR  - http://hdl.handle.net/10138/299135 
T3  -  
A1  - Gershony, Liza C.; Belanger, Janelle M.; Short, Andrea D; Le, Myly; Hytönen, Marjo K.; Lohi, Hannes; Famula, Thomas R; Kennedy, Lorna J; Oberbauer, Anita M. 
A2  -  
PB  - BioMed Central 
Y1  - 2019 
LA  -  
AB  - Abstract
              
                Background
                Primary hypoadrenocorticism (Addison’s disease, AD) and symmetrical lupoid onychodystrophy (SLO) are two clinical conditions with an autoimmune etiology that occur in multiple dog breeds. In man, autoimmunity is associated with polymorphisms in immune-related genes that result in a reduced threshold for, or defective regulation of, T cell activation. The major histocompatibility complex (MHC) class II genes encode molecules that ... 
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IS  -  
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OP  -  
KW  - (3–10): Dog; Autoimmune; MHC; DLA; Addison’s disease; SLO 
N1  -   
PP  -  
ER  -