TY  -  
T1  - DNA hypermethylation appears early and shows increased frequency with dysplasia in Lynch syndrome-associated colorectal adenomas and carcinomas 
SN  -  /  
UR  - http://hdl.handle.net/10138/155696 
T3  -  
A1  - Valo, Satu; Kaur, Sippy; Ristimäki, Ari; Renkonen-Sinisalo, Laura; Järvinen, Heikki; Mecklin, Jukka-Pekka; Nyström, Minna; Peltomäki, Päivi 
A2  -  
PB  - BioMed Central 
Y1  - 2015 
LA  - eng 
AB  - Abstract
              
                Background
                Lynch syndrome (LS) is associated with germline mutations in DNA mismatch repair (MMR) genes. The first “hit” to inactivate one allele of the predisposing MMR gene is present in every cell, contributing to accelerated tumorigenesis. Less information is available of the nature, timing, and order of other molecular “hits” required for tumor development. To this end, MMR protein expression and coordinated promoter methylation were e... 
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