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T1  - DNA methylation of loci within ABCG1 and PHOSPHO1 in blood DNA is associated with future type 2 diabetes risk 
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UR  - http://hdl.handle.net/10138/167097 
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A1  - Dayeh, Tasnim; Tuomi, Tiinamaija; Almgren, Peter; Perfilyev, Alexander; Jansson, Per-Anders; de Mello, Vanessa D.; Pihlajamaki, Jussi; Vaag, Allan; Groop, Leif; Nilsson, Emma; Ling, Charlotte 
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Y1  - 2016 
LA  - eng 
AB  - Identification of subjects with a high risk of developing type 2 diabetes (T2D) is fundamental for prevention of the disease. Consequently, it is essential to search for new biomarkers that can improve the prediction of T2D. The aim of this study was to examine whether 5 DNA methylation loci in blood DNA (ABCG1, PHOSPHO1, SOCS3, SREBF1, and TXNIP), recently reported to be associated with T2D, might predict future T2D in subjects from the Botnia prospective study. We also tested if these CpG site... 
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KW  - ABCG1; adipose tissue; blood; DNA methylation; epigenetics; liver; pancreatic islets; PHOSPHO1; skeletal muscle; type 2 diabetes; EPIGENOME-WIDE ASSOCIATION; HUMAN PANCREATIC-ISLETS; DIFFERENTIAL EXPRESSION; VASCULAR CALCIFICATION; GLUCOSE-TOLERANCE; SKELETAL-MUSCLE; ADIPOSE-TISSUE; LIFE-STYLE; GENES; METABOLISM; 1182 Biochemistry, cell and molecular biology; 3111 Biomedicine 
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