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T1  - DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD 
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UR  - http://hdl.handle.net/10138/197458 
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A1  - Sundar, Isaac K.; Yin, Qiangzong; Baier, Brian S.; Yan, Li; Mazur, Witold; Li, Dongmei; Susiarjo, Martha; Rahman, Irfan 
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Y1  - 2017 
LA  - eng 
AB  - Background: Epigenetics changes have been shown to be affected by cigarette smoking. Cigarette smoke (CS)-mediated DNA methylation can potentially affect several cellular and pathophysiological processes, acute exacerbations, and comorbidity in the lungs of patients with chronic obstructive pulmonary disease (COPD). We sought to determine whether genome-wide lung DNA methylation profiles of smokers and patients with COPD were significantly different from non-smokers. We isolated DNA from parench... 
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KW  - DNA methylation; Lung; Epigenetics; COPD; Smokers; Pyrosequencing; OBSTRUCTIVE PULMONARY-DISEASE; AIRWAY EPITHELIUM TRANSCRIPTOME; CIGARETTE-SMOKE; TOBACCO-SMOKING; DIFFERENTIAL METHYLATION; PROMOTER METHYLATION; GENETIC-VARIATION; CANCER; EXPRESSION; GENOME; 3121 General medicine, internal medicine and other clinical medicine 
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