TY  -  
T1  - Deciphering the Antibacterial Mode of Action of Alpha-Mangostin on Staphylococcus epidermidis RP62A Through an Integrated Transcriptomic and Proteomic Approach 
SN  -  /  
UR  - http://hdl.handle.net/10138/300026 
T3  -  
A1  - Sivaranjani, Murugesan; Leskinen, Katarzyna; Aravindraja, Chairmandurai; Saavalainen, Päivi; Pandian, Shunmugiah Karutha; Skurnik, Mikael; Ravi, Arumugam Veera 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - Background: Alpha-mangostin (alpha-MG) is a natural xanthone reported to exhibit rapid bactericidal activity against Gram-positive bacteria, and may therefore have potential clinical application in healthcare sectors. This study sought to identify the impact of alpha-MG on Staphylococcus epidermidis RP62A through integrated advanced omic technologies. Methods: S. epidermidis was challenged with sub-MIC (0.875 mu g/ml) of alpha-MG at various time points and the differential expression pattern of ... 
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OP  -  
KW  - RNA-sequencing; LC-MS/MS; bactericidal; alpha-mangostin; cytoplasmic membrane; XANTHONE DERIVATIVES; BACILLUS-SUBTILIS; ANTIMICROBIALS; DISCOVERY; PLANT; RESISTANCE; VANCOMYCIN; INHIBITOR; RELEVANCE; BIOFILMS; 3111 Biomedicine; 1183 Plant biology, microbiology, virology 
N1  -   
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ER  -