TY - T1 - Deciphering the Antibacterial Mode of Action of Alpha-Mangostin on Staphylococcus epidermidis RP62A Through an Integrated Transcriptomic and Proteomic Approach SN - / UR - http://hdl.handle.net/10138/300026 T3 - A1 - Sivaranjani, Murugesan; Leskinen, Katarzyna; Aravindraja, Chairmandurai; Saavalainen, Päivi; Pandian, Shunmugiah Karutha; Skurnik, Mikael; Ravi, Arumugam Veera A2 - PB - Y1 - 2019 LA - eng AB - Background: Alpha-mangostin (alpha-MG) is a natural xanthone reported to exhibit rapid bactericidal activity against Gram-positive bacteria, and may therefore have potential clinical application in healthcare sectors. This study sought to identify the impact of alpha-MG on Staphylococcus epidermidis RP62A through integrated advanced omic technologies. Methods: S. epidermidis was challenged with sub-MIC (0.875 mu g/ml) of alpha-MG at various time points and the differential expression pattern of ... VO - IS - SP - OP - KW - RNA-sequencing; LC-MS/MS; bactericidal; alpha-mangostin; cytoplasmic membrane; XANTHONE DERIVATIVES; BACILLUS-SUBTILIS; ANTIMICROBIALS; DISCOVERY; PLANT; RESISTANCE; VANCOMYCIN; INHIBITOR; RELEVANCE; BIOFILMS; 3111 Biomedicine; 1183 Plant biology, microbiology, virology N1 - PP - ER -