TY - T1 - Definitions of Normal Liver Fat and the Association of Insulin Sensitivity with Acquired and Genetic NAFLD - A Systematic Review SN - / UR - http://hdl.handle.net/10138/165225 T3 - A1 - Petäjä, Elina M.; Yki-Järvinen, Hannele A2 - PB - Y1 - 2016 LA - eng AB - Non-alcoholic fatty liver disease (NAFLD) covers a spectrum of disease ranging from simple steatosis (NAFL) to non-alcoholic steatohepatitis (NASH) and fibrosis. "Obese/Metabolic NAFLD" is closely associated with obesity and insulin resistance and therefore predisposes to type 2 diabetes and cardiovascular disease. NAFLD can also be caused by common genetic variants, the patatin-like phospholipase domain-containing 3 (PNPLA3) or the transmembrane 6 superfamily member 2 (TM6SF2). Since NAFL, irre... VO - IS - SP - OP - KW - insulin resistance; liver fat; obesity; PNPLA3; TM6SF2; MAGNETIC-RESONANCE-SPECTROSCOPY; MORBIDLY OBESE-PATIENTS; HEPATIC STEATOSIS; COMPUTED-TOMOGRAPHY; I148M VARIANT; CONFERS SUSCEPTIBILITY; CARDIOVASCULAR-DISEASE; TRIGLYCERIDE CONTENT; DIAGNOSTIC-ACCURACY; METABOLIC SYNDROME; 3121 General medicine, internal medicine and other clinical medicine N1 - PP - ER -