TY  -  
T1  - Design, Synthesis, and Molecular Docking of Paracyclophanyl-Thiazole Hybrids as Novel CDK1 Inhibitors and Apoptosis Inducing Anti-Melanoma Agents 
SN  -  /  
UR  - http://hdl.handle.net/10138/324229 
T3  -  
A1  - Aly, Ashraf A.; Bräse, Stefan; Hassan, Alaa A.; Mohamed, Nasr K.; Abd El-Haleem, Lamiaa E.; Nieger, Martin; Morsy, Nesrin M.; Alshammari, Mohammed B.; Ibrahim, Mahmoud A. A.; Abdelhafez, Elshimaa M. N. 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Three new series of paracyclophanyl-dihydronaphtho[2,3-d]thiazoles and paracyclophanyl-thiazolium bromides were designed, synthesized, and characterized by their spectroscopic data, along with X-ray analysis. One-dose assay results of anticancer activity indicated that 3a-e had the highest ability to inhibit the proliferation of different cancer cell lines. Moreover, the hybrids 3c-e were selected for five-dose analyses to demonstrate a broad spectrum of antitumor activity without apparent selec... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - paracyclophane; thiazole; apoptosis; CDK1; 1; 4-naphthoquinone; antitumor; melanoma; molecular docking; 116 Chemical sciences; 1182 Biochemistry, cell and molecular biology 
N1  -   
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ER  -