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T1  - Desmoglein 3-Influence on oral carcinoma cell migration and invasion 
SN  -  /  
UR  - http://hdl.handle.net/10138/243574 
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A1  - Apu, Ehsanul Hoque; Akram, Saad Ullah; Rissanen, Jouni; Wan, Hong; Salo, Tuula 
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PB  -  
Y1  - 2018 
LA  - eng 
AB  - Desmoglein 3 (Dsg3) is an adhesion receptor in desmosomes, but its role in carcinoma cell migration and invasion is mostly unknown. Our aim was to quantitatively analyse the motion of Dsg3-modified carcinoma cells in 2D settings and in 3D within tumour microenvironment mimicking (TMEM) matrices. We tested mutant constructs of C-terminally truncated Dsg3 (Delta 238 and Delta 560), overexpressed full-length (FL) Dsg3, and empty vector control (Ct) of buccal mucosa squamous cell carcinoma (SqCC/Y1)... 
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KW  - Desmoglein 3; 3D in vitro model; Co-culture; Myogel; Migration; Invasion; Live cell imaging; Cell tracking; Image analysis; Monoclonal antibody testing; TUMOR MICROENVIRONMENT; EXTRACELLULAR-MATRIX; CANCER PROGRESSION; PROTEIN-KINASE; STROMA; HEAD; INTERFACE; PHENOTYPE; ADHESION; TARGET; 3122 Cancers; 1182 Biochemistry, cell and molecular biology; 313 Dentistry 
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